Like others, I have a 2 tier system.
About 2TB of my (Synology) NAS is critical files. Those get sent via Hyperbackup to cloud storage on at least a weekly basis, some daily. I have them broken up into multiple tasks with staggered schedules so it never has much to do on any given day.
The other 16TB I have get sync'd (again with hyperbackup, but not a scheduled backup task) to a 20TB external drive roughly once per quarter. Then that drive lives on the closet of a family member.