MoCa adapters are a decent option if running new cable is difficult, but 10 gig adapters still aren't available.

If you want 10 gig, run fiber, not CAT6. Twisted pair uses a lot of power. Fiber uses less than a watt per port and is future proof.

I looked at using moca for some things before, the spec supports 10gb, but I could only find adapters up to 2.5. My main questions for you is what effort vs performance do you want. Moca adapters are $50ish each, how many endpoints do you expect and are you ok with 2.5gbs or less at each?

Also worth noting, moca is right now 2.5gbps on the line half duplex, which is much slower than 10gbps full duplex per broadcast domain of a Ethernet cable

This looks WILDLY similar to my old setup! If you've got really old RG59 in there, it's going to suck - horrible jitter, and sub-1gig for sure, and obviously the longer the run the worse it gets.

If you throw 2.5 Gbps adapters on to a nice clean piece of new RG6 though, especially point to point (but then you'd lose this boost), it is not terrible.

In the end it was just a stopgap, I think I used it for about 5 years and then the first time I was having work done and had some parts of the walls open I got my guy to run fibre everywhere he could, and cat8 everywhere else. I do still use one of the RG59 links, just joined at that panel, to do a point to point from an upstairs bedroom, down through the basement and back up to the living room, just carrying super low volume corosync traffic for one of my lab clusters - but all the rest is migrated off now and is a way less frustrating connection now.

I may reuse one of the good RG6 through cinderblock pieces to do RS485 between my ERV and my Home Assistant Yellow at some point in the future, but for the most part the coax is now abandoned (and we flipped the house to fibre internet years ago too.)