There often aren't major cultural differences, not the abruptly, but there still can be changes. Sometimes the road will be 2 lanes on one side and 4 on the other. Sometimes you'll see a ton of new billboards on one side and not the other because they just bought a bunch in one state. Architecture? Not so much, I don't think, though it could be in some areas. Generally if someone is actively picking something while they're there,like building a house, it won't change, but if it's someone picking or choosing something from afar like what a road should be like or what to advertise it can change abruptly.
A good example is that in the past (not so much now), I-75 going south into Georgia began to have a ton of weird pro life billboards and Christian billboards once you cross the state line. Since then they have passed the line, but for real, it was a very abrupt change from none to tons of pictures of fetuses and talking points about when "your baby's" heart beat begins. As well as weird pictures of an apocalypse and Jesus that just sort of says "do you have a decision to make?" With no context.
I actually signed that last one's website's guest book to tell them the domain name on their signs was wrong, which was hilarious to me. It seems like the site would come before the billboards, so why wouldn't they notice the billboards had the wrong site? It was something like org instead of com, pretty minor. But sure enough they changed the billboards next time I went to Florida. So clearly someone is maintaining that site and those billboards. I just checked and it's still up, but it looks like they have some redirects now. So, maybe they fixed some stuff or my memory is fuzzy, this was probably about 10 years ago, definitely pre COVID though.