this post was submitted on 31 Mar 2026
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[–] Buffalox@lemmy.world 43 points 1 month ago* (last edited 1 month ago) (62 children)

analysed reviews of evidence from animal studies,

I seriously doubt that, because the bases in e-juice were studied thoroughly in the 50's with no such evidence.
And nicotine has obviously also been studied thoroughly, and the nicotine is not considered a major carcinogen in cigarettes, it's mostly compounds created by the burning of the paper and tobacco that cause cancer that is the actual SMOKE in smoking, which vapes do not have, unless the vape is seriously overheated.

I bet that this study is flawed, if it truly shows indication of cancerous effects, I bet it's because they overheat the e-juice, which has the same effect as burning fat on a frying pan. And with the e-juice taste horribly.
Either that or they've used impure products, and not the pharmaceutical quality products that dominate the industry.
If you are a vaper, make sure the nicotine and base juice are both pharmaceutical quality.

However, the review included case reports from dentists who noticed oral cancer in people who had only vaped and who had never smoked.

This is partially based on self reporting, which is the least reliable form of study there is.
Also I've never heard such warnings from dentists?

Unfortunately with these kinds of studies, we have to consider they can either be honestly flawed, but worse than that the studies can be dishonest to attract funding.

[–] kieron115@startrek.website 4 points 1 month ago* (last edited 4 weeks ago) (11 children)

afaik the bases of e-juice were studied for ingestion, not inhalation.

edit: i was thinking of diacetyl which is sometimes used as a flavoring additive and caused a bunch of lung injury in the early days of microwave popcorn manufacturing. While looking through these I stumbled upon vitamin e acetate (used as a condensing agent in vape products) and it sounds none to good for you either. https://pmc.ncbi.nlm.nih.gov/articles/PMC6952050/

[–] rabidhamster@lemmy.dbzer0.com 2 points 4 weeks ago (1 children)

Vitamin E acetate was found in grey market THC vapes as a thickener.

The 2019 panic was mostly caused by kids who got hospitalized, and didn't want to admit they'd been using THC.

[–] kieron115@startrek.website 1 points 4 weeks ago* (last edited 4 weeks ago)

the pubmed article is like 5 years old so it's entirely possible that it isn't used anymore, but at the time they found it in JUUL pods and all sorts of other nicotine-based vape fluids (as well as yeah the grey-market thc vapes). I think the best advice is probably what someone else down below said, try to get pharmaceutical-grade which means it only has chemicals deemed safe for human consumption.

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