this post was submitted on 10 Apr 2026
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Watson beat Ken Jennings over a decade ago. Protein folding was already done too, the people who did it even won a Nobel prize for it a couple years ago.
LLMs being the most visible part of AI after over 75 years of AI, isn’t because they’re the biggest or latest or greatest or whatever, it’s marketing. Plain and simple marketing.
Probably more that it's the only AI normal people will interact with regularly. Your average person isn't going to run a protein folding application, but they will probably talk to chatgpt or use Google AI summaries.
Protein folding is far from "done" lol. Models have gotten a lot better but there is still more to do.
I didn’t say it was finished. I said people had won a Nobel prize for having done it. It takes decades to win a Nobel prize. My point was that it had been done years and years ago, not recently.
Anfinsen won the Nobel in 1972 for showing that the amino acid sequence is what is responsible for the 3D structure of proteins.
Since then we've been able to take images of protein's structures using xray crystallography but that is a painstaking process. The ability to accurately predict a protein's structure from an amino acid sequence has been an unsolved problem until very recently.
It wasn't until 2024 that Hassabis, Jumper and Baker won the Nobel for their work in predicting protein structure (using an AI called AlphaFold) and computationally designing new proteins.
The ability to create arbitrary proteins is new and will revolutionize some fields of medicine (like cancer treatment) and, to me, is a much more impressive use of AI.
LLMs are interesting but they are incredibly over-hyped as far as 'changing the world' goes, imo.
They won the prize for an AI they made in the early 2000s.