Fr. 1000 equates to $1,235 (and yes, there's a single bill worth that) along with the second highest being Fr. 200 ($247) since the cap in USD maxes out at $100 (Fr. 81) in the US today. There were once $500, $1000, $5000 & $10,000 bills printed in 1928 but ceased reappearing since 1934, only sole collectors have them but they don't use it for transactions (the $100,000 bill depicting Woodrow Wilson is obscure and not possible to obtain).
spoiler
And yes, this bill is currently in circulation around Switzerland.
What would it be like if suddenly a $1000 bill reemerges from its older design from the 1930s tweaked with modern security features inspired by the Fr. 1000 bill stronger than ones present in the $100 bill? That's up the Federal Reserve to decide, there's issues dealing with counterfeit $100 bills, in which the Swiss managed to prevent by making their Fr. 1000 bill difficult as hell to counterfeit. (It's hard enough to find one the first place).
Iโd only buy drugs with bills that large. Everything else goes on the card.