this post was submitted on 02 Nov 2025
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Both are already OTC in most of the world, specifically most developing countries.
More importantly, you are applying an insane and bad-faith standard when assessing medication. ANY medication can have lethal side effects. Down a bottle full of Tylenol and you'll condemn yourself to a slow agonizing death of liver failure. Yet you can buy that shit at gas stations.
You answered the wrong question. You asked, "can HRT be dangerous?" Any rational person trying to form an unbiased opinion about it would ask, "is HRT of comparable risk to existing OTC medications?"
In countries besides America, Tylenol comes in blister packs of maybe 20 total pills per package in a lower dose than the American variation. The drug and marketing regulations here are not a good example and I think a lot of medications that are currently OTC need to be much more closely regulated or have things like the inconvenient packaging and MUCH better warnings on them for patient safety.
That being said, poorly managed (or un-managed) HRT has more potential for significant harm than most OTC medications. There are many complications that can come from exogenous hormone treatment for both trans and cis patients, and the risks need to be adequately assessed and managed. Estrogen significantly increases the risk of blood clots and strokes, and Testosterone drastically increases the risk of heart attack and organ failure if not dosed appropriately.
In no way do I intend to restrict trans healthcare, but most medications on the market in America need to be much more closely regulated than they are now because of the risks of harms that can vastly outweigh the benefits, especially when not dosed or monitored accurately.
You're spreading anti trans FUD. The risks are extremely modest. The risks you cite, like heart attack risk on T, are just from moving an FTM person from a female to make heart attack profile. Men have a greater risk of heart attack than women do. Having a male hormone profile gives you male health risks. But people like you like to spread fear by citing this as an effect of HRT.
You're portraying hrt as this crazy substance, but we're talking bioidentical hormones here. They are the same exact molecules that are produced naturally.
You are shamelessly spreading anti trans propaganda. Or take estrogen for example. Trans women raise their E levels to the 100-300 range, the normal female E range. Yet cis women, when pregnant, experience E levels 10-20 times those levels. The human body can handle very high levels of estrogen quite well. You can take 10x the recommended E dose and still be extremely unlikely to have any adverse effects from it.
Show me one single person that has died from the misuse of modern bioidentical hormones. Find me one. Because hrt is absolutely far safer than almost every otc medication out there. You can literally take 10x the recommended doses. That's how safe it is. It's safe because we're talking the exact same molecules that are made by the body.
There's a reason diy is so common among the trans community. Even most doctors are comically ignorant and repeat long disproven myths like the ones you repeat here.
HRT is extremely safe when dosed appropriately. As I said in another comment, I'm less worried about trans folks getting the HRT wrong than cis people taking a bunch of extra hormones because some influencer convinced them that more estrogen or more testosterone will fix all their health problems. Making something OTC makes it available to everyone, not just the people that need it. Trans people need HRT, cis people very rarely do.
And yet, other countries where HRT is OTC don't have an epidemic of cis kids dead from taking T and E. Your concern is purely hypothetical. Meanwhile we have real world data showing the risks of OTC HRT are minimal. And even cis people taking it have very low risks, comparable to other otc medications.
Social media leads people to do all sorts of stupid things. We don't ban bleach because someone might try and drink it to cure covid.
It isn't the cis kids I worry about. It's the menopausal woman in the emergency department with a DVT and PE from the estrogen she got online on the advice of her chiropractor. It's the man in his 50's that thought testosterone would fix his lost libido and fatigue that now has to get coronary artery stents because he got his dosing recommendations from body building influencers.
It's the real patients I have seen and treated that concern me when these hormones aren't even that freely available. It's not a hypothetical for me, it's real people that have suffered real harm even if they didn't die from it.