Signalis is fantastic, it blends the careful resource/inventory management of classic RE with the somber psychological storytelling of Silent Hill (specifically inspired by SH 1-3).
The basic premise is that you're an android named Elster searching for your lost human co-pilot after crashing your ship. The environments range from industrial machinery, to hellish twisting labyrinths, to dense urban corridors. The game is surreal, has an incredible soundtrack, and tells an emotional non-linear story. Highly recommend it.