You could always play with mods. One of them adds pollution scrubbers, which you can surround your base with to make sure biters are never prompted to attack in the first place. I have several hundred hours in one save that has a metaphoric wall of filters that has yet to be attacked outside of a few instances when I was expanding.
Out of curiosity and just for the novelty of doing it, I found another mod that made a combinator device which would output the current pollution for the chunk that it was contained within. Using that, I set up a whole system to turn on the exact number of scrubbers I needed to prevent any pollution from leaving my base. Never actually implemented it because it was wildly impractical, but it was a fun project just to see if I could do it.
His wife already did, along with a lot of other stuff.