Not sure if you're using a desktop or laptop (unclear if you're doing DJ stuff for mixing privately or gigging on the road), but hardware passthrough through something like SR-IOV would make latency a non-issue.
However, I get what you're saying. I was more thinking of the "I want to run this on a legacy operating system for as long as I can" aspect of things. Eliminating the concern of the hardware no longer supporting a more modern operating system was what I was trying to get at. Sorry if that didn't come through.
They mention their equipment is legacy and only supports Windows 10. An Airgapped VM of Windows 10 is a good option to continue supporting legacy hardware.