Just don’t get a portable unit. They suck and are just a waste of money most of the times.
Get a dual-hose unit if you get one. There are a lot of companies selling single-hose units. Those are a lot less efficient and aren't much cheaper. I would guess that in a situation where they get any kind of meaningful use, a dual-hose unit pays for itself quickly.
I don't think I'd agree that they suck, but if you can use a window unit
not all rooms and windows are amenable to this
you normally want a window unit instead of a portable unit, unless you must take down the AC unit on a regular basis. Less noise inside, more energy efficiency.
Mini splits don't provide ventilation, whereas ducted systems do. In general, if one can have a ducted system, I'd rather have that. The major problem with ducted systems is that ductwork takes up a lot of space, so it's hard to stick into an existing house; much less of an issue if you can build it in during construction. A mini split is less invasive to an existing structure.