Again, it works until it requires reloading, i.e. the next update of any component or the next restart of the server.
I'm also running an inode cache on the client side, on top of the persistent opcache, but due to the sheer number of files that Nextcloud consists of it still generates a frankly ridiculous amount of calls when it needs to invalidate the cache. If you're running on local drives then that's likely much less of an issue, regardless of what kind of drive it is, but this is hosted on machines that do not have any local storage.
Oh yeah, CPU usage is basically zero, and memory usage of the PHP code itself is also basically nil compared to other software I run. It's just the sudden storms of IO requests that causes issues, and since those come over a network pipe it causes issues for other pieces of software as well.